Most Extreme Humans: Story, Cast and Series Facts

Story and premise

Most Extreme Humans follows people from around the globe living with the world's rarest and most remarkable physical conditions. From a Filipino man whose hands have grown so large he wears wristwatches as rings, to Brazil, where the world's smallest married couple have a combined height under six feet, to a 19-year-old in India living with the ultra-rare condition known as "werewolf syndrome." This series examines what everyday life looks like when the world is not built with your body in mind.

Series details

• Title: Most Extreme Humans
• Format: Reality
• Language: English
• Genres: Medical
• Premiere date: 2026-06-10
• Status in TVmaze: Running
• Network listed by TVmaze: TLC
• Network country: United States
• Typical episode runtime: 60 minutes
• TVMaze ID: 91889
• IMDb ID: tt43455095
• TVDB ID: 479083

Seasons in the TVmaze catalogue

• Season 1: premiered 2026-06-10; final listed air date 2026-08-12; episode order: 10.

Source and licence

Adapted from Most Extreme Humans on TVmaze. The synopsis is reproduced as plain text; catalogue facts, cast and season records are selected and reformatted. This adapted text is available under CC BY-SA 4.0, following the TVmaze API licence. Network and web-channel credits identify the service listed in this source; they do not establish current streaming availability.